research and knowledge

Randomized, placebo controlled, double-blind study

Femiano F et al., (2011) compared in a randomized, double blind, placebo controlled, parallel study the efficacy of saliva substitutes and citric acid long-term therapyfor oral dryness relief and unstimulated salivary flow in patients reporting drug-induced...

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Randomized, double-blind, crossover study

Jellema AP et al., (2001) evaluated in a randomized, double blind, placebo controlled, crossover study the efficacy of Xialine® (xanthan gum) saliva substitute spray in 30 patients (aged 46-79 years) with radiation-induced xerostomia for 1 week per phase, overall 3...

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Randomized, double-blind, crossover study

Morales-Bozo I et al., (2012) evaluated the efficacy of two mouthrinses in the reduction of xerostomía-associated symptomatology in a randomized, double-blind, cross-over clinical trial with progressive recruitment and a washout period, in 67 adult patients with...

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Randomized, double-blind, placebo controlled, study

Ship JA et al., (2007) evaluated the safety and efficacy of a group of topical dry mouth products (toothpaste, mouth rinse, mouth spray and gel) containing olive oil, betaine and xylitol in a randomized, single-blinded, controlled, cross-over clinical study in 40...

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Randomized, controlledclinical trial

Silvestre FJ et al., (2009) demonstrated in a randomized, controlled clinicalstudy the subjective improvement afforded by a new artificial saliva in spray form containing an aqueous solution of mineral salts, xylitol and citric acid, in 37 elderly patients (aged over...

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Randomized, placebo controlled, double-blind study

Van der Reijden WA et al., (1996) examined in a randomized, double-blind, placebo-controlled trial the efficacy of 3 types of polymer-based saliva substitutes in reducing oral dryness in 43 patients (aged 25-79 years) with primary and secondary Sjögren’s syndrome for...

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